Tributyrin (Igituntu)naMonolaurine (GML)Nk’inyongeramusaruro ku biryo, bigira ingaruka nyinshi ku miterere y’umubiri mu bworozi bw’inkoko zo mu byiciro, bikongera cyane imikorere y’umusaruro w’amagi, ubwiza bw’amagi, ubuzima bw’amara, ndetse n’imikorere y’ibinure mu mara. Dore imirimo n’uburyo byakozwemo by’ingenzi:

1. Kunoza umusaruro w'amagi
Gliseroli Monolaurate(GML)

Kongeramo 0.15-0.45g/kg GML mu ndyo y'inkoko zitera amagi bishobora kongera cyane umusaruro w'amagi, kugabanya umuvuduko wo guhindura ibiryo, no kongera uburemere bw'igi.
Ubushakashatsi bwerekana ko 300-450mg/kg GML ishobora kongera umusaruro w'amagi y'inkoko zitera amagi no kugabanya umuvuduko w'amagi afite inenge.

Tributyrin (Igituntu) 

Mu igerageza ry’inkoko z’inkoko, 500mg/kg TB ishobora gutinza igabanuka ry’umusaruro w’amagi mu gihe cyo gutera amagi, kongera imbaraga z’ibishishwa by’amagi, no kugabanya umuvuduko wo gusohora amagi.
Bihujwe naGML(nk'ifuru ifite patenti) ishobora kongera igihe cyo gutanga amagi menshi no kunoza inyungu mu bukungu.

2. Kongera ubwiza bw'igi

Imikorere ya GML
Ongera uburebure bwa poroteyine, ushyireho ibipimo bya Haff (HU), kandi wongere ibara ry'umuhondo.
Hindura imiterere ya aside irike y'umuhondo w'igi, wongere aside irike ya polyunsaturated (PUFA) na aside irike ya monounsaturated (MUFA), kandi ugabanye ingano ya aside irike ya saturated (SFA).

Ku gipimo cya 300mg/kg, GML yongereye cyane ubukana bw'igi ry'igi n'ingano ya poroteyine y'umweru w'igi.

Imikorere yaTB

Ongera imbaraga z'ibishishwa by'amagi kandi ugabanye umuvuduko wo kwangirika kw'ibishishwa (nk'ukugabanya 58.62-75.86% mu igerageza).

Guteza imbere igaragara ry'uturemangingo tujyanye no gushyira kalisiyumu mu mura (nka CAPB-D28K, OC17) no kunoza ubwiyongere bw'ibishishwa by'igi.

3. Kugenzura imikorere y'ibinure mu mubiri n'imikorere y'ubudahangarwa bw'umubiri
Imikorere ya GML
Kugabanya triglycerides mu maraso (TG), cholesterol yose (TC), na cholesterol ifite ubucucike buke (LDL-C), no kugabanya ibinure byo mu nda.
Kunoza imikorere ya serum superoxide dismutase (SOD) na glutathione peroxidase (GSH Px), kugabanya ingano ya malondialdehyde (MDA), no kongera ubushobozi bwo kurwanya antioxidant.
Imikorere yaTB
Kugabanya ingano ya triglyceride mu mwijima (10.2-34.23%) no kongera imiterere y’uturemangingo dufitanye isano no gushonga kw’ibinure (nk’urugero rwa CPT1).
Kugabanya urugero rwa alkaline phosphatase (AKP) na MDA mu maraso, no kongera ubushobozi bwose bwa antioxydants (T-AOC).

4. Kunoza ubuzima bw'amara
Imikorere ya GML
Ongera uburebure bwa villus na villus kuri villus ratio (V/C) bya jejunum kugira ngo urusheho kunoza imiterere y'amara.
Gabanya ibintu bitera ububyimbirwe (nka IL-1 β, TNF - α), wongere ibintu birwanya ububyimbirwe (nka IL-4, IL-10), kandi wongere imikorere y'amara.
Kunoza imiterere ya mikorobe zo mu bwoko bwa cecal, kugabanya igipimo cya bagiteri za Proteobacteri, no guteza imbere ikura rya bagiteri z'ingirakamaro nka Spirogyraceae.
Imikorere ya TB
Hindura agaciro ka pH y'amara, uteze imbere ikwirakwira rya bagiteri nziza (nka lactobacilli), kandi uhagarike bagiteri mbi.
Kongera imikorere ya poroteyine ifatanye mu buryo buhamye (nka Occludin, CLDN4) byongera ubusugire bw'amara.

5. Ingaruka ku budahangarwa bw'umubiri
Imikorere ya GML
Kunoza igipimo cy'umusemburo n'igipimo cya thymus, kongera imikorere y'ubudahangarwa bw'umubiri.
Gabanya ibimenyetso by'ubushyuhe mu maraso nka aspartate aminotransferase (AST) na alanine aminotransferase (ALT).
Imikorere ya TB
Kugabanya ingaruka z'ububyimbirwe mu mara binyuze mu kugenzura inzira ya Toll like receptor (TLR2/4).

6. Ingaruka zo gukoresha hamwe
Ubushakashatsi bwa patenti bwagaragaje ko uruvange rwa GML na TB (nk'ibice 20-40 TB+15-30 GML) bishobora kongera umusaruro w'inkoko zitera amagi (92.56% ugereranyije na 89.5%), kugabanya ububyimbirwe bw'imiyoboro y'amazi, no kongera igihe cyo gutanga amagi menshi.

Incamake:

Glycerol Monolaurate (GML)naTributyrin (igituntu)bigira ingaruka zuzuzanya mu bworozi bw'inkoko:

GMLbibanda kurikunoza ubwiza bw'igi, kugenzura imikorere y'ibinure mu mubiri, no kurwanya imisemburo mibi;
TBbibanda kurikunoza ubuzima bw'amara no gutunganya kalisiyumu;
Uruvange rushoborabitanga ingaruka nziza ku buryo buhuriweho, bikongera umusaruro w’amagi mu buryo bwuzuye ndetse bikanazamura ubwiza bw’amagi.