Nk'intangiriro ya aside butyric,tributyl glycerideni inyunganiramirire nziza ya aside butyric ifite imiterere ihamye y’umubiri n’iya chimique, umutekano n’ingaruka mbi zitarimo uburozi. Ntabwo ikemura gusa ikibazo cy’uko aside butyric ihumura nabi kandi igahinduka mu buryo bworoshye, ahubwo inakemura ikibazo cy’uko aside butyric igoranye gushyirwa mu gifu no mu mara. Ifite amahirwe menshi yo gukoreshwa mu bijyanye n’imirire y’amatungo. Nk’inyongeramusaruro,tributyl glycerideishobora gukora ku buryo butaziguye ku nzira y’igogora ry’amatungo, igatanga ingufu mu nzira y’igogora, ikongera ubuzima bw’amara y’amatungo, kandi ikagenzura imikurire n’ubuzima bw’amatungo.

1. Kunoza imikorere y'iterambere

Kongerahotributyl glycerideKugaburira byakoreshejwe cyane mu gukora amatungo y’ubwoko bwose. Kongera ingano ikwiye ya tributyl glyceride mu ndyo bishobora kongera ibiro by’amatungo yageragejwe buri munsi, kugabanya igipimo cy’ibiryo ugereranije n’ibiro, no kunoza imikorere y’amatungo. Ingano y’inyongera ni 0.075% ~ 0.250%.

2. Kunoza ubuzima bw'amara

TributyrinBishobora kugira uruhare runini mu buzima bw'amara y'inyamaswa binyuze mu kunoza imiterere n'imiterere y'amara, kugenzura uburinganire bw'ibimera byo mu mara, kunoza ubushobozi bw'amara n'ubudahangarwa bw'ingufu. Ubushakashatsi bwagaragaje ko kongera igituntu mu mirire bishobora kongera imiterere ya poroteyine ihuza amara n'amara, guteza imbere iterambere ry'amara, kunoza igogorwa ry'intungamubiri z'ibiryo, kongera ubushobozi bwo kurwanya ubudahangarwa bw'ingufu, kugabanya ingano ya bagiteri mbi mu mara no kongera ingano ya bagiteri z'ingirakamaro, guteza imbere iterambere ry'amara y'amatungo, no kunoza ubuzima bw'amara y'amatungo.

Hari ubushakashatsi bumwe na bumwe bwagaragaje ko kongera igituntu mu ndyo bishobora kongera cyane uburyo poroteyine zikomoka ku bimera, ibinure n'ingufu by'ingurube zo mu gituza zigogora, kandi uburyo intungamubiri zikomoka ku biryo bigogora bifitanye isano rya hafi n'ubuzima bw'amara y'inyamaswa. Bigaragara ko igituntu gitera imbaraga mu kwinjiza no gusya intungamubiri mu mara.

Inyongera yatributyl glycerideishobora kongera cyane uburebure bwa villus n'agaciro ka V/C k'amara y'abana b'ingurube zonsa, ikagabanya ingano ya MDA na hydrogen peroxide muri jejunum, yongera imikorere ya mitochondrial, igagabanya stress ya oxidative mu bana b'ingurube, kandi igateza imbere iterambere ry'amara.

Kongeramo tributyl glyceride ifite utunyangingo duto bishobora kongera cyane uburebure bwa duodenum na jejunum, kongera ingano ya bagiteri za aside lactic muri cecum no kugabanya ingano ya Escherichia coli, kunoza imiterere y'ibimera byo mu mara by'inkoko, kandi ingaruka za TB ifite utunyangingo duto ni nziza kuruta iz'igituntu cy'amazi. Bitewe n'uruhare rwihariye rw'uruhu rw'inyama z'inkoko mu nyama z'inkoko, hari raporo nke zigaragaza ingaruka za tributyl glyceride ku nyama z'inkoko.

Kubera ko tributyrin ari yo itera imbaraga mu mara, ishobora kunoza no gusana imiterere n'imiterere y'amara, kunoza igogora n'ubushobozi bwo kwinjiza amara, guteza imbere ukwiyongera kwa bagiteri zigira akamaro mu mara, kunoza imiterere y'ibimera mu mara, kugabanya ingaruka mbi ku nyamaswa, guteza imbere iterambere ry'amara, no gutuma umubiri ugira ubuzima bwiza.

Ubushakashatsi bwagaragaje ko kongeramo ibintu byinshi byatributyrinn'amavuta ya oregano cyangwa salicylate ya methyl mu mirire y'abana b'ingurube bakuweho bishobora kongera agaciro ka V/C k'amara, kunoza imiterere y'amara y'abana b'ingurube, kongera cyane ubwinshi bwa Firmicutes, kugabanya ubwinshi bwa Proteus, Actinobacillus, Escherichia coli, n'ibindi, guhindura imiterere y'ibimera byo mu mara n'ibinyabutabire, ibyo bikaba ingirakamaro ku buzima bw'amara y'abana b'ingurube bakuweho ...

Muri rusange,tributyrinIfite imirimo itandukanye ya biyoloji nko gutanga ingufu ku mubiri, kubungabunga ubuziranenge bw'amara, kugenzura imiterere y'ibimera byo mu mara, kugira uruhare mu mikorere y'ubudahangarwa bw'umubiri n'imikorere y'umubiri, nibindi. Ishobora guteza imbere iterambere ry'amara y'inyamaswa no kunoza imikorere y'imikurire y'amatungo. Glyceryl tributylate ishobora kubora na pancreas lipase mu mara kugira ngo ikore aside butyric na glycerol, bishobora gukoreshwa nk'isoko nziza ya aside butyric mu mara y'inyamaswa. Ntabwo ikemura gusa ikibazo cy'uko aside butyric bigorana kongeramo mu biryo bitewe n'impumuro yayo no guhinduka kwayo, ahubwo inakemura ikibazo cy'uko aside butyric bigorana kwinjira mu mara binyuze mu gifu. Ni umuti uvura indwara za antibiyotike w'icyatsi kibisi kandi ukora neza cyane.

Ariko, ubushakashatsi buri gukorwa ubu ku ikoreshwa ryatributyl glycerideMu mirire y’amatungo ni bake cyane, kandi ubushakashatsi ku ngano, igihe, imiterere n’uruvange rw’igituntu n’izindi ntungamubiri burabura cyane. Gushimangira ikoreshwa rya tributyl glyceride mu musaruro w’amatungo ntibishobora gutanga gusa uburyo bushya bwo kwita ku buzima bw’amatungo no kwirinda indwara, ahubwo binagira akamaro kanini mu guteza imbere imiti isimbuza imiti yica udukoko, hamwe n’amahirwe menshi yo kuyikoresha.