aside Guanilasetike, izwi kandi nka aside guanilacetike, ni aside amine igereranywa ikomoka kuri glycine na L-lysine.

Aside ya Guanilacetike ishobora gukora creatine binyuze mu gukata enzymes kandi ni yo yonyine isabwa kugira ngo creatine ikoreshwe. Creatine izwi nk'ikintu gitanga ingufu, kandi inshingano yayo nyamukuru ni ugukora creatine ikoresheje phosphoryline ikoresheje creatine kinase.

Jya mu rugendo rwo gutera adenosinehosphate (ATP). Iyo ingufu za ATP zidahagije, fosfocreatine yimura vuba itsinda rya fosfate kuri adenosine diphosphate binyuze muri creatine kinase maze ikayisubiza muri adenosine triphosphate.

 

Gukoresha mu matungo y'inyamaswa zo mu bwoko bwa "beeminant":

Kongeraho aside guanilacetique 0.12%, 0.08%, na 0.04% ku ndyo y’intama 120 zorojwe mu kiraro zipima ibiro bigera kuri 20, byagaragaje ko kongeramo aside guanilacetique 0.12% na 0.08% byongera cyane ibiro bya buri munsi, ibinure byo mu mitsi, na poroteyine, kandi bigabanya cyane ibinure byo mu nyamaswa.

 

Kongeraho 0.08%aside guanilasetikebiyongereyeho 9.77% ku nyama z’inka ku kigero cya 9.77%. Hakoreshejwe uburyo bwo gukora imyuka muri vitro, hakozwe ubushakashatsi ku ngaruka zo kongeramo ingano zitandukanye za aside guanilacetike ku matungo y’inka z’umuhondo. Byagaragaye ko kongeramo aside guanilacetike 0.4% byongera cyane umusaruro wa gaze, kandi ubwinshi bwa azote ya ammonia bwabanje kwiyongera hanyuma bukagabanuka.

Bityo rero, bishobora gufatwa nk'aho kongeramo aside guanilacetike mu biryo bya buri munsi bishobora kunoza imiterere y'imbere mu nda y'inka z'umuhondo ndetse no gutuma inka z'umuhondo zikora neza.

Gukoresha mu nkoko:

Kongera 800 mg/kg, 1600 mg/kg, 4000 mg/kg, na 8000 mg/kg bya aside guanylacetic mu biryo bya buri munsi by’inkoko z’inkoko byagaragaje ko kongera 800-4000 mg/kg bya aside guanylacetic mu biryo byongereye cyane ibiro by’inkoko z’inkoko buri munsi, bigabanya igipimo cy’ibiryo ku buremere bw’inkoko z’inkoko ku minsi 22-42. Kongera 8000 mg/kg bya aside guanylacetic byazamuye ibipimo bya biochemical mu maraso nka azote ya urea, ibipimo by’imikorere y’amaraso, na bilirubin yose Nta ngaruka nini yagaragaye ku bipimo by’ingenzi by’ingingo, bigaragaza ko kongera 8000 mg/kg bya aside guanylacetic mu biryo bya buri munsi by’inkoko z’inkoko biremewe.

Kongeramo 200 mg/kg, 400 mg/kg, 600 mg/kg, na 800 mg/kg bya aside guanilacetic mu ifu y’inka byagaragaje ubwiyongere bugaragara bw’ibiro bya buri munsi ugereranije n’itsinda ryagenzuwe. Ibisubizo byiza byabonetse ubwo urugero rw’inyongera rwari 600 mg/kg.

Kugira ngo hamenyekane ingaruka za aside guanylacetic ku bwiza bw'intanga mu nkoko, inkoko 20 zifite ibyumweru 28 zatoranijwe kugira ngo zigaburire indyo irimo 0%, 0.06%, 0.12%, na 0.18% ya aside guanylacetic. Ibisubizo by'ubushakashatsi byagaragaje ko kongera aside guanylacetic 0.12% mu ndyo byongera cyane umubare w'intanga, ubwinshi bw'intanga mu nkoko, n'imikorere y'intanga mu nkoko, bigaragaza ko kongera aside guanylacetic mu ndyo bishobora kunoza ubwiza bw'inkoko. Ongeraho aside guanylacetic 0.0314%, 0.0628%, 0.0942%, na 0.1256% mu biryo bya buri munsi by'inkoko, kandi hagashyirwaho amatsinda abiri yo kugenzura (itsinda rya 1 ryo kugenzura ni ibiryo bishingiye ku bimera bidafite ikintu na kimwe cyongewemo, naho itsinda rya 2 ryo kugenzura ni ibiryo birimo ifunguro ry'amafi). Amatsinda atandatu yavuzwe haruguru y'ibiryo bya buri munsi afite urwego rumwe rw'ingufu n'imyunyungugu.

Ibisubizo by'igerageza bigaragaza ko igipimo cy'ubwiyongere bw'ibiro by'amatsinda ane yongewemo aside guanilacetique n'itsinda rya 2 ry'igenzura kiri hejuru kurusha icy'itsinda rya 1 ry'igenzura, Itsinda rya 2 ry'igenzura ryagize ingaruka nziza zo kwiyongera ibiro, rikurikirwa n'itsinda rya 0.0942% rya aside guanilacetique; Itsinda rya 2 ry'igenzura ryagize igipimo cyiza cy'ibikoresho ku buremere, rikurikirwa n'itsinda rya 0.1256% rya aside guanilacetique.

Gukoresha mu nkoko:

Kongeramo 800 mg/kg, 1600 mg/kg, 4000 mg/kg, na 8000 mg/kg byaaside guanilasetikeKu biryo bya buri munsi by’inkoko z’inkoko byagaragaje ko kongera 800-4000 mg/kg bya aside guanylacetic ku biryo byongera cyane ibiro by’inkoko z’inkoko ku munsi, bigabanya igipimo cy’ibiryo ku biryo by’inkoko z’inkoko ku buremere bw’inkoko ku minsi 22-42. Kongera 8000 mg/kg bya aside guanylacetic byazamuye ibipimo bya biochemical mu maraso nka azote ya urea, ibipimo by’imikorere y’amaraso, na bilirubin yose Nta ngaruka nini zabayeho ku bipimo by’ingenzi by’ingingo, byerekana ko kongera 8000 mg/kg bya aside guanylacetic ku biryo bya buri munsi by’inkoko z’inkoko byihanganirwa. Kongera 200 mg/kg, 400 mg/kg, 600 mg/kg, na 800 mg/kg bya aside guanylacetic ku biryo by’inkoko by’inkoko byagaragaje ubwiyongere bugaragara bw’ibiro bya buri munsi ugereranije n’itsinda ryagenzuwe. Ibisubizo byiza byabonetse ubwo urugero rwo kongeramo rwari 600 na 800 mg/kg.

Kugira ngo hamenyekane ingaruka za aside guanylacetic ku bwiza bw'intanga mu nkoko, inkoko 20 zifite ibyumweru 28 zatoranijwe kugira ngo zigaburire indyo irimo 0%, 0.06%, 0.12%, na 0.18% ya aside guanylacetic. Ibisubizo by'ubushakashatsi byagaragaje ko kongera aside guanylacetic 0.12% mu ndyo byongera cyane umubare w'intanga, ubwinshi bw'intanga mu nkoko, n'imikorere y'intanga mu nkoko, bigaragaza ko kongera aside guanylacetic mu ndyo bishobora kunoza ubwiza bw'inkoko. Ongeraho aside guanylacetic 0.0314%, 0.0628%, 0.0942%, na 0.1256% mu biryo bya buri munsi by'inkoko, kandi hagashyirwaho amatsinda abiri yo kugenzura (itsinda rya 1 ryo kugenzura ni ibiryo bishingiye ku bimera bidafite ikintu na kimwe cyongewemo, naho itsinda rya 2 ryo kugenzura ni ibiryo birimo ifunguro ry'amafi). Amatsinda atandatu yavuzwe haruguru y'ibiryo bya buri munsi afite urwego rumwe rw'ingufu n'imyunyungugu. Ibisubizo by'igerageza bigaragaza ko igipimo cyo kwiyongera ibiro kw'amatsinda ane yongewemo aside guanilacetique n'itsinda rya 2 ry'igenzura kiri hejuru kurusha icy'itsinda rya 1 ry'igenzura, Itsinda rya 2 ry'igenzura ryagize ingaruka nziza zo kwiyongera ibiro, rikurikirwa na 0.0942%aside guanilasetikeitsinda; Itsinda rya 2 ry’igenzura ryari rifite igipimo cyiza cy’ibikoresho ugereranyije n’uburemere, rikurikirwa n’itsinda rya aside guanilacetique rya 0.1256%.