Ubundi buryo bwo kuvura hifashishijwe imiti igabanya ubukana bw’ibiyobyabwenge burakenewe bitewe n’uko iyi miti yabujijwe gukoreshwa nk’imiti itera imbere mu buhinzi bw’amatungo. Tributyrin isa nkaho igira uruhare mu kunoza imikorere y’ingurube, nubwo ifite ubushobozi butandukanye.

Kugeza ubu, nta byinshi bizwi ku ngaruka zabyo ku miterere ya mikorobe zo mu mara. Muri ubu bushakashatsi, twasesenguye impinduka za mikorobe zo mu mara ku bana b'ingurube bahabwa, mu gihe cyo konka, 0.2% bya tributyrin byongewe mu ndyo yabo y'ibanze.

Itsinda rya Tributyrin ryari rifite ubushobozi bwo kongera ingufu mu mikorere y’ingufu n’ubushobozi buke mu mikorere y’isukari. Mu gusoza, ibyavuye mu bushakashatsi bwacu byagaragaje ko tributyrin ishobora guteza impinduka mu miterere y’udukoko two mu mara, ibyo bikaba byafasha mu kunoza imikorere y’amatungo nyuma yo konka.

Ingaruka za Tributyrin ku Guhindura Imiterere ya Microbiota mu Gifu Bijyanye n'Imikorere y'Ingurube Zirimo Gucutsa

Ibipimo by'ibicuruzwa

Tributyrin (izina kandi nka Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate) ni ubwoko bwa ester y'ibinure by'uruhererekane rugufi.

CAS RN: 60-01-5

Nimero ya EINECS: 200-451-5

Formula: C15H26O6

FW: 302.36

Ishusho: Ni amazi y'amavuta y'umweru kugeza ku muhondo afite impumuro y'ibinure bike.

Gushonga: Bishongera muri ethanol, chloroform na ether, ntibishongera cyane mu mazi (0.010%).

Igihe cyo kuruhuka: Amezi 24

Ipaki: 25KG/ Ishakoshi

Ububiko: Bufunze ahantu humutse kandi hahumeka umwuka

Tributyrinni triglyceride irimo molekile eshatu za butyrate zahinduwe glycerol, yongera ingano ya butyrate nyuma yo gushonga na pancreas lipases.

Ibiranga Tributyrin
Ivuka rishya rya ester ya butyrate-glycerol ya aside butyric.
100% by'inda inyura mu nda.
Gutanga aside butyric mu mara mato, ntabwo ari ngombwa ko ipfukwa.
Bisanzwe biboneka mu mata no mu buki.

Kugereranya Tributyrin na Butyrate Umunyu

Igice cy'ubuzima cya aside butyric ni iminota 6. Butyrate iragoye kugera ku zindi ngingo n'ingingo zitari mu mara itangwa mu buryo bwa aside butyric cyangwa butyrate. Nyamara igice cy'ubuzima cya tributyrin ni iminota 40, kandi igipimo cya butyrate mu mara gishobora kuguma hejuru ya 0.1mM mu gihe cy'amasaha 0.5-4 ukoresheje umunwa.

Imiterere n'Ibiranga

Umutanga Ingufu

Nkuko bizwi cyane, aside butyric ni aside irike y’uruhererekane rugufi, ikaba ari yo soko nyamukuru y’ingufu z’uturemangingo tw’ingirabuzima fatizo z’amara. Ingufu zirenga 70% zo gukura kw’uturemangingo tw’ingirabuzima fatizo z’amara zitangwa na aside butyric. Ariko, tributyrin itanga agaciro kanini ka aside butyric isohora amara ugereranije n’ibindi bicuruzwa bya butyrate.

Kurinda amara

►Tributyrin itera kwiyongera no gutandukanya uturemangingo tw’uturemangingo tw’amara, igasana uturemangingo twangiritse, kandi ikagura ubuso kugira ngo intungamubiri zijye mu mubiri.

►Tributyrin ifasha mu kugaragaza poroteyine zihuza imiterere y’uturemangingo mu mara, ikomeza guhuza uturemangingo, ikarinda uturemangingo nka bagiteri n’uburozi kwinjira mu mubiri, kandi igakomeza gukora neza kw’uturemangingo tw’amara.

►Tributyrin iteza imbere isohoka rya mucin (Muc) kandi igakomeza imikorere y'ibinyabutabire byo mu mara.

Igipimo cyo kubaho cyariyongereye

Tributyrin ishobora guteza imbere ikorwa rya hemoglobin, kongera ubushobozi bwo gutwara ogisijeni, gukomeza sisitemu y’ubuzima bw’umubiri, kandi ishobora kunoza imikorere ya mitochondria no guteza imbere ikorwa rya ATP, ari yo ngirabuzimafatizo ituma ubuzima bukomeza, kugira ngo yongere umubare w’abazima cyangwa inyamaswa.

Irwanya ububyimbirwe n'udukoko twa mikorobe

►Mu kubuza imikorere ya NF-Kb, TNF-α na TLR, Tributyrin ishobora kugabanya kwangirika kw'ububyimbirwe.

►Tributyrin iteza imbere imikorere ya peptides zo mu bwoko bwa endogenous defense, zishobora kurwanya indwara yanduza na virusi muri rusange.