Inyongera ku biryo: Tributyrin

Ibikubiye muri iki gitabo: 95%, 90%

Tributyrin nk'inyongeramusaruro mu kuzana iterambere mu mara y'inkoko.

Guhagarika imiti yica udukoko nk'ibitera iterambere ry'inkoko mu buryo bwo kuyikoresha byazamuye ubushake bwo gukoresha izindi ngamba z'imirire, haba mu kongera imikorere y'inkoko ndetse no kurinda indwara ziterwa n'indwara.

Kugabanya ububabare bwa dysbacteriosis
Kugira ngo habeho kugenzura imiterere y’indwara zo mu bwoko bwa dysbacteriosis, harimo kongerwamo ibiryo nk’ibinini bya probiotics na prebiotics kugira ngo bigira uruhare mu ikorwa rya SCFAs, cyane cyane aside butyric igira uruhare runini mu kurinda inzira y’amara. Aside butyric ni SCFA isanzwe ifite ingaruka nyinshi nziza nko kurwanya ububyimbirwe, ingaruka zayo mu kwihutisha inzira yo gusana amara no gushishikariza iterambere rya villi mu nda. Hari uburyo bwihariye aside butyric ikora binyuze mu buryo bwo gukumira ubwandu, ari bwo Host Defense Peptides (HDPs), izwi kandi nka peptides zirwanya mikorobe, zikaba ari ingenzi mu bigize ubudahangarwa bw’umubiri. Zifite imikorere yagutse yo kurwanya mikorobe mu kurwanya bagiteri, ibihumyo, parasite na virusi zitwikiriye, ibyo bikaba bigoye cyane ko udukoko twandura turwanya. Defensins (AvBD9 & AvBD14) na Cathelicidins ni zo miryango ibiri ikomeye ya HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) iboneka mu nkoko iterwa imbaraga no kongeramo aside butyric. Mu bushakashatsi bwakozwe na Sunkara et. al. Gutanga aside butyric hanze bitera kwiyongera gukomeye kwa gene ya HDP bityo bikongera ubushobozi bwo kurwanya indwara mu nkoko. Igishimishije ni uko LCFAs ziri hagati yazo kandi zikaba nkeya.

Akamaro ka Tributyrin ku buzima
Tributyrin ni igikoresho cya mbere cya aside butyric gituma molekile nyinshi za aside butyric zijya mu mara mato mu buryo butaziguye bitewe n’uburyo bwo gupima. Bityo, ingano yazo iba iri hejuru inshuro ebyiri cyangwa eshatu ugereranyije n’ibicuruzwa bisanzwe bitwikiriwe. Gupima esterification bituma molekile eshatu za aside butyric zihuzwa na glycerol ishobora kwangirika gusa na pancreas lipase.
Li et al. bashyizeho inyigo y’ubudahangarwa bw’umubiri kugira ngo barebe ingaruka nziza za tributyrin ku matungo y’inkoko atera ububyimbirwe mu matungo y’inkoko ahanganye na LPS (lipopolysaccharide). Gukoresha LPS bizwi cyane ko bitera ububyimbirwe mu bushakashatsi nk’ubu kuko bitera ibimenyetso by’ububyimbirwe nka IL (Interleukins). Ku minsi ya 22, 24, na 26 y’igerageza, amatungo y’inkoko yarwanyijwe hakoreshejwe 500 μg/kg BW LPS cyangwa saline mu nda. Kongera tributyrin mu mirire ya 500 mg/kg byabujije IL-1β na IL-6 kwiyongera, bigaragaza ko kongerera kwayo bishobora kugabanya irekurwa rya matungo atera ububyimbirwe bityo bigagabanya ububyimbirwe mu mara.

Incamake
Hamwe n’ikoreshwa rito cyangwa itegeko ribuza burundu imiti imwe n’imwe itera indwara zo mu mara gukura nk’inyongera ku biryo by’amatungo, ingamba nshya zo kunoza no kurinda ubuzima bw’amatungo yo mu rugo zigomba gucukumburwa. Ubusugire bw’amara bukora nk’ihuriro ry’ingenzi hagati y’ibikoresho fatizo bihenze by’ibiryo n’iterambere ry’inkoko zo mu rugo. Aside butyrique cyane cyane izwiho kuba itera imbaraga mu kongera ubuzima bw’igifu imaze imyaka irenga 20 ikoreshwa mu biryo by’amatungo. Tributyrind itanga aside butyrique mu mara mato kandi igira ingaruka nziza ku buzima bw’amara binyuze mu kwihutisha ibikorwa byo gusana amara, itera imbaraga iterambere ryiza rya villi no guhindura imikorere y’ubudahangarwa bw’umubiri mu mara.

Ubu imiti yica udukoko irimo gukurwaho, aside butyric ni igikoresho cyiza cyo gushyigikira inganda mu kugabanya ingaruka mbi za dysbacteriosis zigaragara bitewe n'iyi mpinduka.