Sodium Butyrate cyangwa tributyrin'Ni iyihe wahitamo'?

Bizwi cyane ko aside butyric ari isoko y'ingufu ku turemangingo tw'inda nini. Byongeye kandi, ni yo soko y'ibikomoka kuri peteroli ikundwa cyane kandi itanga kugeza kuri 70% by'ingufu zose zikenera. Ariko, hari ubwoko bubiri bwo guhitamo. Iyi nkuru itanga igereranya rya byombi, ifasha gusubiza ikibazo 'ni iyihe wahitamo'?

Ikoreshwa rya butyrate nk'inyongeramusaruro ku biryo by'amatungo ryakozweho ubushakashatsi bwinshi kandi rikoreshwa mu buhinzi bw'amatungo mu myaka myinshi ishize, ryabanje gukoreshwa mu nka kugira ngo ritere imbere mu matungo mbere yo gukoreshwa mu ngurube n'inkoko.

Inyongeramusaruro za butyrate zagaragaje ko zituma umubiri wiyongera ibiro (BWG) kandi zigahindura ibiryo (FCR), zigabanya impfu kandi zikagabanya ingaruka z'indwara ziterwa n'amara.

Isoko rikunze kuboneka rya aside butyric yo kugaburira amatungo riza mu buryo bubiri:

1. Nk'umunyu (ni ukuvuga Sodium butyrate) cyangwa
2. Mu buryo bwa triglyceride (ni ukuvuga Tributyrin).

Hanyuma haza ikibazo gikurikiraho –Ni iyihe mpitamo?Iyi nkuru itanga igereranya ry’ibi byombi ku ruhande rumwe.

Uburyo bwo gukora

Sodiyumu butyrate:Bikorwa binyuze mu buryo bwa aside-base reaction kugira ngo habeho umunyu ufite aho ushongesha cyane.

NaOH+C4 H8 O2=C4 H7 COONa+H2O

(Sodium Hydroxide + aside Butyric = Sodium Butyrate + Amazi)

Tributyrin:Ikorwa binyuze mu gupima aho aside butyric 3 ifatanye na glycerol kugira ngo ikore tributyrin. Tributyrin ifite aho ishongera cyane.

C3H8O3 + 3C4H8O2 = C15 H26 O6 + 3H2O

(Glycerol + aside butyric = Tributyrin + Amazi)

Ni iyihe itanga aside butiriki nyinshi kuri kilo y'ibicuruzwa?

KuvaImbonerahamwe ya 1, tuzi ingano ya aside butyric iri mu bicuruzwa bitandukanye. Ariko, tugomba no gusuzuma uburyo ibi bicuruzwa bisohora aside butyric mu mara neza. Kubera ko butyrate ya sodium ari umunyu, ishongera mu mazi isohora butyrate, bityo dushobora gutekereza ko 100% bya butyrate iva muri butyrate ya sodium izarekurwa iyo ishongeye. Kubera ko butyrate ya sodium itandukana byoroshye, imiterere irinzwe (ni ukuvuga micro-encapsulation) ya butyrate ya sodium izayifasha kugera ku kurekura butyrate buhoro buhoro mu mara kugeza ku mara.

Tributyrin mu by’ukuri ni triacylglyceride (TAG), ikaba ari ester ikomoka kuri glycerol na aside 3 z’ibinure. Tributyrin isaba lipase kugira ngo irekure butyrate ifatanye na glycerol. Nubwo tributyrin imwe irimo butyrate 3, si butyrate zose 3 zemejwe ko zizarekurwa. Ibi biterwa nuko lipase ihitamo neza. Ishobora gukurura triacylglycerides kuri R1 na R3, R2 gusa, cyangwa atari yo yihariye. Lipase kandi ifite umwihariko wa substrate kuko enzyme ishobora gutandukanya imiyoboro ya acyl ifatanye na glycerol no guca ubwoko bumwe na bumwe. Kubera ko tributyrin isaba lipase kugira ngo irekure butyrate yayo, hashobora kubaho ipiganwa hagati ya tributyrin n'izindi TAG kuri lipase.

Ese sodium butyrate na tributyrin bigira ingaruka ku ifunguro ryinjira?

Sodium butyrate ifite impumuro mbi idashimishije abantu ahubwo ikunzwe n'inyamaswa zo mu bwoko bwa breast. Sodium butyrate igizwe na 3.6-3.8% by'ibinure by'amata biri mu mata y'ibere, bityo, ishobora gukora nk'ikintu gikurura ibiryo bigatera imbaraga zo kubaho kw'inyamaswa zo mu bwoko bwa breast (Imbonerahamwe ya 2). Ariko, kugira ngo amara asohoke buhoro buhoro, sodium butyrate ikunze gushyirwamo igitambaro cy’ibinure (ni ukuvuga Palm stearin). Ibi kandi bifasha mu kugabanya impumuro mbi ya sodium butyrate.

Ku rundi ruhande, Tributyrin nta mpumuro ifite ariko ifite uburyohe butuma umuntu acika intege (Imbonerahamwe ya 2). Kongeramo byinshi bishobora kugira ingaruka mbi ku kurya ibiryo. Tributyrin ni molekile isanzwe ishobora kunyura mu gice cyo hejuru cy'igifu kugeza igihe icitsemo lipase mu mara. Nanone ntihinduka mu bushyuhe bw'icyumba, bityo muri rusange ntabwo ipfukwa. Tributyrin ikunze gukoresha dioxyde silica idafite ishingiro nk'umutwaro wayo. Dioxyde silica ifite imyenge kandi ishobora kudasohora tributyrin neza mu gihe cyo gusya. Tributyrin kandi ifite umuvuduko mwinshi w'umwuka utuma ihinduka iyo ishyushye. Kubwibyo, turasaba tributyrin gukoreshwa mu buryo bwa emulsified cyangwa mu buryo burinzwe.